abstract：:Low-dose naltrexone (LDN) has been demonstrated to reduce symptom severity in conditions such as fibromyalgia, Crohn's disease, multiple sclerosis, and complex regional pain syndrome. We review the evidence that LDN may operate as a novel anti-inflammatory agent in the central nervous system, via action on microglial ...

journal_title：Clinical rheumatology

authors： Younger J,Parkitny L,McLain D

更新日期：2014-04-01 00:00:00

abstract：:Severe thrombocytopenia with bleeding associated with a life-threatening thrombotic manifestation in the setting of antiphospholipid syndrome is a major diagnostic and therapeutic challenge for the clinician. Hemorrhage is a less common complication than thrombosis in patients with APS, although severe thrombocytopeni...

journal_title：Clinical rheumatology

authors： Nyo MT,Kalla AA

更新日期：2014-04-01 00:00:00

abstract：:The aim of this study was to evaluate whether modifiable cardiovascular disease (CVD) risk factors, e.g. atherogenic blood lipids, hypertension and lifestyle-related factors such as smoking, diet and physical inactivity, differ among patients with ankylosing spondylitis (AS) in comparison to the general population. Ei...

journal_title：Clinical rheumatology

authors： Sundström B,Johansson G,Johansson I,Wållberg-Jonsson S

更新日期：2014-01-01 00:00:00

abstract：:The burden of non-communicable diseases such as musculoskeletal diseases in the developing world is often overshadowed by the more prevalent infectious diseases. Generally, there is gross underestimation of the burden of rheumatologic disease in the backdrop of scanty or indeed non-existent rheumatology services in th...

journal_title：Clinical rheumatology

authors： Chipeta J,Njobvu P,McGill PE,Bucala R

更新日期：2014-01-01 00:00:00

abstract：:The objectives of this study are to assess the risk of asymptomatic cranial neuropathy among patients with systemic lupus erythematosus (SLE) and find any association with disease activity and antiribosomal P antibodies. This study is a case-control study including 60 female patients and 30 healthy female controls. Di...

journal_title：Clinical rheumatology

authors： Gaber W,Ezzat Y,El Fayoumy NM,Helmy H,Mohey AM

更新日期：2014-01-01 00:00:00

abstract：:Psoriatic arthritis (PsA) is a chronic T cell-mediated inflammatory spondyloarthropathy affecting 10-40 % of psoriasis (PSO) patients (0.3-1.0 % of the general population). Recent epidemiological studies have shown an increased prevalence of cardiovascular (CV) risk factors and/or morbidity among PSO or PsA patients a...

journal_title：Clinical rheumatology

authors： Khraishi M,Aslanov R,Rampakakis E,Pollock C,Sampalis JS

更新日期：2014-01-01 00:00:00

abstract：:Behcet's disease (BD) is a multisystemic disorder characterised by recurrent oral and genital ulcers. Vasculitis and thrombotic events are the most important causes of mortality. Thrombosis is the major clinical finding in patients with BD, but the cause of the thrombosis is still unclear. Thromboelastography is an al...

journal_title：Clinical rheumatology

authors： Yaşar Bilge NŞ,Akay OM,Kaşifoğlu T,Kuş G,Korkmaz C

更新日期：2013-12-01 00:00:00

abstract：:Abnormalities in B cell are characteristic feature of primary Sjögren's syndrome (pSS). As FcγRIIb is a key regulator of B cells, the objective of this study is to investigate the role of the inhibitory receptor FcγRIIb in B cells from pSS patients, and whether glucocorticoid can affect B cell subpopulations or FcγRII...

journal_title：Clinical rheumatology

authors： Chen H,Zhou S,Su D,Lu L,Li X,Sun L

更新日期：2013-12-01 00:00:00

abstract：:In this study, we aimed to evaluate the relation between angiogenesis indicators and T helper 17 cytokine group in patients with systemic sclerosis (SSc) which is a disease characterized by impaired angiogenesis and autoimmune response. In our study, patients with SSc are compared with patients with primary Raynaud's ...

journal_title：Clinical rheumatology

authors： Aydoğdu E,Pamuk ÖN,Dönmez S,Pamuk GE

更新日期：2013-11-01 00:00:00

abstract：:There is an increasing concern over generalizability of trial results. We investigated eligibility criteria of knee osteoarthritis clinical trials. Eligible trials were randomized, placebo-controlled trials that were identified by searches in MEDLINE, SCOPUS, and the Cochrane Central Register of Controlled Trials. We ...

journal_title：Clinical rheumatology

authors： Koog YH,Wi H,Jung WY

更新日期：2013-11-01 00:00:00

abstract：:While fibromyalgia is frequently associated with ear-related symptoms such as feeling of ear fullness, earache, and tinnitus, the pathogenesis of these ear-related symptoms in fibromyalgia patients is unknown. Here, we focused on clarifying the pathogenesis of ear fullness, a particularly common symptom observed in fi...

journal_title：Clinical rheumatology

authors： Iikuni F,Nomura Y,Goto F,Murakami M,Shigihara S,Ikeda M

更新日期：2013-10-01 00:00:00

abstract：:Vitamin D deficiency may be involved in the pathogenesis of several inflammatory conditions. This study aimed to determine the status of vitamin D in the rheumatology patients who were diagnosed with different rheumatic, inflammatory and non-inflammatory diseases. In this cross-sectional observational study, we review...

journal_title：Clinical rheumatology

authors： Alachkar M,Teoh YP,O'Sullivan MM

更新日期：2013-10-01 00:00:00

abstract：:This study aims to explore patient's concerns when discussing sexual problems caused by chronic low back pain with their healthcare provider. It also aims to identify factors influencing and limiting such communication. A cross-sectional analysis of 100 consenting chronic low back pain sexually active patients was car...

journal_title：Clinical rheumatology

authors： Bahouq H,Allali F,Rkain H,Hajjaj-Hassouni N

更新日期：2013-10-01 00:00:00

abstract：:We investigated the clinical characteristics, management modalities, and outcomes in patients with relapsing polychondritis (RP) with airway involvement. The medical records of RP patients with airway involvement seen at Samsung Medical Center from August 2004 to December 2011 were collected. The clinical manifestatio...

journal_title：Clinical rheumatology

authors： Hong G,Kim H

更新日期：2013-09-01 00:00:00

abstract：:This study aims to compare the mean platelet volume (MPV) levels in children and adults diagnosed with familial Mediterranean fever (FMF) during attack-free periods in order to find out whether it reflects the emergence of microalbuminuria/proteinuria and the development of amyloidosis or not. The study consisted of 6...

journal_title：Clinical rheumatology

authors： Sakallı H,Kal O

更新日期：2013-08-01 00:00:00

abstract：:The purpose of the study was to assess the 1-year outcome of definitive reactive arthritis (ReA) after a waterborne outbreak. A cohort of 21 patients (15 females and 6 males, median age 54 years) with ReA related to an extensive waterborne outbreak in Finland was clinically followed-up by rheumatologists with visits a...

journal_title：Clinical rheumatology

authors： Uotila TM,Antonen JA,Paakkala AS,Mustonen JT,Korpela MM,Pirkanmaa Waterborne Outbreak Study Group.

更新日期：2013-08-01 00:00:00

abstract：:Severe exacerbation of symptoms following physical activity is characteristic for chronic-fatigue syndrome (CFS) and fibromyalgia (FM). These exacerbations make it understandable for people with CFS and FM to develop fear of performing body movement or physical activity and consequently avoidance behaviour toward phys...

journal_title：Clinical rheumatology

authors： Nijs J,Roussel N,Van Oosterwijck J,De Kooning M,Ickmans K,Struyf F,Meeus M,Lundberg M

更新日期：2013-08-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a multi-system chronic inflammatory disease with a broad spectrum of clinical and serological manifestations. Although clinical evidence of proximal skeletal muscle involvement is not rare in patients with SLE, there is no knowledge about the effects of SLE on the macroscopic stru...

journal_title：Clinical rheumatology

authors： Kaya A,Kara M,Tiftik T,Tezcan ME,Ozel S,Ersöz M,Göker B,Haznedaroğlu S,Ozçakar L

更新日期：2013-08-01 00:00:00

abstract：:This study demonstrates whether serum β2-microglobulin (β2-MG) level can be an indicator of the status of systemic lupus erythematosus (SLE) and adult-onset Still's disease (AOSD), and development of hemophagocytic syndrome (HPS) complication. Serum β2-MG level was compared between the active and inactive statuses of ...

journal_title：Clinical rheumatology

authors： Wakabayashi K,Inokuma S,Matsubara E,Onishi K,Asashima H,Nakachi S,Hagiwara K

更新日期：2013-07-01 00:00:00

abstract：:Autonomic nervous system (ANS) involvement has been studied in systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, Sjogren's syndrome, and ankylosing spondylitis but still has not been studied in psoriatic arthritis (PsA). The aim of this study was to investigate the prevalence and the nature of au...

journal_title：Clinical rheumatology

authors： Syngle A,Verma I,Garg N,Krishan P

更新日期：2013-07-01 00:00:00

abstract：:In patients with rheumatoid arthritis who had symptomatic knee joints at the start of anti-tumor necrosis factor (TNF) therapy, the relationship between local symptoms and knee joint destruction at 94 weeks was retrospectively investigated. Among the patients with rheumatoid arthritis and received anti-TNF therapy, th...

journal_title：Clinical rheumatology

authors： Imagama T,Tanaka H,Tokushige A,Seki K,Sumiura S,Yamamoto M,Nagahiro Y,Taguchi T

更新日期：2013-06-01 00:00:00

abstract：:Idiopathic retroperitoneal fibrosis (IRPF) is a rare condition of unknown aetiology characterized by chronic non-specific inflammation of the retroperitoneum. The aim of this study is to describe, for the first time, the features of Spanish patients with IRPF. In this retrospective study, a clinical description was pe...

journal_title：Clinical rheumatology

authors： Fernández-Codina A,Martínez-Valle F,Castro-Marrero J,Detorres I,Vilardell-Tarrés M,Ordi-Ros J

更新日期：2013-06-01 00:00:00

abstract：:We investigated the association between smoking and the disease activity, functional ability, physical mobility, and systemic inflammation in Chinese ankylosing spondylitis (AS) patients. Seventy five male Chinese AS patients in Taiwan were enrolled in the cross-sectional study. These patients fulfilled the 1984 modif...

journal_title：Clinical rheumatology

authors： Chen CH,Chen HA,Lu CL,Liao HT,Liu CH,Tsai CY,Chou CT

更新日期：2013-05-01 00:00:00

abstract：:The objective of this study was to identify predictors for remission or low disease activity (LDA) in established rheumatoid arthritis (RA) at 12 months of anti-TNF-α therapy. We have performed a prospective observational study in 90 consecutive patients with active RA receiving TNF-α inhibitors. Baseline and standard...

journal_title：Clinical rheumatology

authors： Pomirleanu C,Ancuta C,Miu S,Chirieac R

更新日期：2013-05-01 00:00:00

abstract：:The aim of this study was to describe how persons with rheumatoid arthritis (RA) of working age experience and handle their fatigue in everyday life. Six focus group discussions were conducted focusing on experiences of fatigue in 25 persons with RA (19 women, 6 men), aged 20-60 years. The discussions were recorded, t...

journal_title：Clinical rheumatology

authors： Feldthusen C,Björk M,Forsblad-d'Elia H,Mannerkorpi K,University of Gothenburg Centre for Person-Centred Care (GPCC).

更新日期：2013-05-01 00:00:00

abstract：:The aim of this study was to investigate whether calcium pyrophosphate dihydrate (CPPD) crystals are constantly detectable in sequential synovial fluid (SF) examinations of patients with initially CPPD-positive osteoarthritis (OA). For this purpose, we searched our SF database for CPPD-positive patients, who had two o...

journal_title：Clinical rheumatology

authors： Robier C,Neubauer M,Fritz K,Lippitz P,Stettin M,Rainer F

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:To determine incidence of increased levels of alanine transferase (ALT) >2× upper limit of normal (ULN) in patients receiving methotrexate (MTX), treated according to a dynamic strategy, and to identify predictors of ALT of >2× ULN. METHODS:Data of 508 recent-onset rheumatoid arthritis (RA) patients from the...

journal_title：Clinical rheumatology

authors： Dirven L,Klarenbeek NB,van den Broek M,van Groenendael JH,de Sonnaville PB,Kerstens PJ,Huizinga TW,Dijkmans BA,Lems WF,Allaart CF

更新日期：2013-05-01 00:00:00

abstract：:An association has been demonstrated between haemorrhoids and joint hypermobility. Reasons for this are discussed. Many performing artists are hypermobile and the extra-articular features of joint hypermobility should not be forgotten or underestimated as a potential constraint upon performance. ...

journal_title：Clinical rheumatology

authors： Yousif UN,Bird HA

更新日期：2013-04-01 00:00:00

abstract：:The objective of this study was to describe ultrasonography (US) and magnetic resonance imaging (MRI) findings at painful Achilles tendons and entheses in patients with and without spondyloarthropathy (SpA and non-SpA) and healthy control persons (CTRLs). Particularly, we aimed to investigate if any changes differenti...

journal_title：Clinical rheumatology

authors： Wiell C,Szkudlarek M,Hasselquist M,Møller JM,Nørregaard J,Terslev L,Ostergaard M

更新日期：2013-03-01 00:00:00

abstract：:The swift and accurate diagnosis of acute arterial occlusion and limb ischemia is critical to prevent morbidity from this vascular emergency as reported by Bettman et al. (Radiology 215:101-105, 2000). There are a number of imaging modalities available to the diagnosing physician. However, the most appropriate modalit...

journal_title：Clinical rheumatology

authors： Baker JF,Nazarian LN,Olin JW,Pullman-Mooar S

更新日期：2013-03-01 00:00:00

abstract：:Delayed diagnosis in patients with Churg-Strauss syndrome (CSS) is largely attributed to the variable and nonspecific presentation of the disease's initial symptoms. The aim of the study was to evaluate the effect of delayed diagnosis on the course of CSS. We conducted a retrospective study of 30 CSS patients followed...

journal_title：Clinical rheumatology

authors： Sokołowska B,Szczeklik W,Mastalerz L,Kuczia P,Wodkowski M,Stodółkiewicz E,Macioł K,Musiał J

更新日期：2013-03-01 00:00:00

abstract：:Type B insulin resistance syndrome is characterized by the formation of autoantibodies against insulin receptors, which can cause severe hyperglycemia and insulin resistance. Systemic lupus erythematosus is the most common underlying diseases of the syndrome. This report details our study of a case involving a Chinese...

journal_title：Clinical rheumatology

authors： Zhang S,Wang G,Wang J

更新日期：2013-02-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-alpha) plays an important role in the pathogenesis of chronic inflammatory diseases, i.e., rheumatoid arthritis (RA), ankylosing spondylitis (AS), Crohn's disease (CD), and ulcerative colitis (UC). Anti-TNF-alpha strategies are successfully used in their treatment. However, their effec...

journal_title：Clinical rheumatology

authors： Tomáš L,Lazúrová I,Pundová L,Oetterová M,Zakuciová M,Petrášová D,Studenčan M

更新日期：2013-01-01 00:00:00

abstract：:Antiglomerular basement membrane antibody disease (aGD) remains a very uncommon entity in the pediatric population, characterized by pulmonary hemorrhage, glomerulonephritis, and antibodies against the glomerular basement membrane. We herein describe the case of a 14-year-old girl with primary pulmonary symptoms diagn...

journal_title：Clinical rheumatology

authors： Bayat A,Kamperis K,Herlin T

更新日期：2012-12-01 00:00:00

abstract：:To examine the relationship between physical appearance concern and psychological distress in female adolescent patients with systemic lupus erythematosus (SLE) was the aim of this study. A total of 84 adolescent SLE female patients and 80 age-matching healthy adolescents were evaluated for levels of appearance concer...

journal_title：Clinical rheumatology

authors： Ji L,Lili S,Jing W,Yanyan H,Min W,Juan X,Hongmei S

更新日期：2012-12-01 00:00:00

abstract：:Ankylosing spondylitis (AS) is the prototype for spondyloarthritis primarily affecting young men. Geographic and ethnic variations exist in the prevalence and severity of AS and relate to the wide disparity in the frequency of human leukocyte antigen (HLA)-B27, a major genetic risk factor. The strength of the disease ...

journal_title：Clinical rheumatology

authors： Rachid B,El Zorkany B,Youseif E,Tikly M

更新日期：2012-11-01 00:00:00

abstract：:Fragile X mental retardation 1 (FMR1) premutation carriers, who are at risk of having children with fragile X Syndrome, were initially considered as clinically unaffected. However, recent clinical and molecular studies have shifted this point of view. The incidence of premutation in the general population is substanti...

journal_title：Clinical rheumatology

authors： Martorell L,Tondo M,Garcia-Fructuoso F,Naudo M,Alegre C,Gamez J,Genovés J,Poo P

更新日期：2012-11-01 00:00:00

abstract：:The aim of the study was to demonstrate the effectiveness of sulphurous water in patients with osteoarthritis of the hand. Forty-seven patients with osteoarthritis of the hand were enrolled into the double-blind, randomized, controlled study, satisfying ACR criteria. One group of the patients (n = 24) received balneot...

journal_title：Clinical rheumatology

authors： Kovács C,Pecze M,Tihanyi Á,Kovács L,Balogh S,Bender T

更新日期：2012-10-01 00:00:00

abstract：:This paper presents the first reported case of risedronate-associated scleritis and conducts a review of bisphosphonates and inflammatory eye diseases. A case of scleritis associated with risedronate use in a 73-year-old Chinese woman is reported. The English medical literature was reviewed for bisphosphonates and the...

journal_title：Clinical rheumatology

authors： Hemmati I,Wade J,Kelsall J

更新日期：2012-09-01 00:00:00

abstract：:This pilot study aimed to evaluate the correlation between clinical symptoms and cartilage volume through MRI in patients with knee osteoarthritis after 48 weeks of treatment with Structum®. Multicenter, double-blind, placebo-controlled, parallel-group study. Symptomatic knee osteoarthritis patients aged 50-75 years r...

journal_title：Clinical rheumatology

authors： Railhac JJ,Zaim M,Saurel AS,Vial J,Fournie B

更新日期：2012-09-01 00:00:00